The United States and Israel launched a major attack on Iran on Saturday, striking Tehran, the capital, and other large cities in an assault that threatened a broader regional conflict. U.S. and Israeli officials have said that the initial wave of strikes targeted Iranian leadership, military assets and nuclear facilities.

Israel and the United States launched a joint preemptive military operation against Iran, deploying a vast array of advanced air, naval and missile systems. Israel's Operation Roaring Lion and the US-led Operation Epic Fury struck Iranian military and nuclear-linked sites,

President Donald Trump placed a huge wager by launching a massive air assault on Iran despite having done little to prepare Americans for a new Middle East war with immense risks and years of future consequences.

Iranian supreme leader Ayatollah Ali Khamenei has been killed in a series of US-Israeli strikes across Iran, Donald Trump has said. The US and Israel struck dozens of targets in the attacks, including the supreme leader’s compound. Iranian authorities say the strikes killed at least hundreds of people on Saturday morning.

Indirect talks between the U.S. and Iran have wrapped, and a deal was not reached on Tehran's nuclear program. NPR's weekly national security podcast Sources & Methods explores what's next.